Although Decentralized Finance (DeFi) applications facilitate tamper-proof transactions among multiple anonymous users, since attackers can access the smart contract bytecode directly, vulnerabilities in the transaction mechanism, contract code, or third-party components can be easily exploited to manipulate token prices, leading to financial losses. Since price manipulation often relies on specific states and complex trading sequences, existing detection tools have limitations in addressing this problem. In addition, to swiftly identify the root cause of an attack and implement targeted defense and remediation measures, auditors typically prioritize understanding the methodology behind the attack, emphasizing `how' it occurred rather than simply confirming its existence. To address these problems, this paper presents a novel automatic price manipulation detection and analysis framework, named DeFort, which contains a price manipulation behavior model to guide on-chain detection, multiple price monitoring strategies to detect pools with abnormal token prices, and various profit calculation mechanisms to confirm attacks. Based on behavioral models, DeFort can automatically locate transactions and functions that cause abnormal price fluctuations and identify attackers and victims. Experimental results demonstrate that DeFort can outperform state-of-the-art price manipulation detection methods. Furthermore, after monitoring 441 real-world projects for two months, DeFort successfully detected five price manipulation attacks.